SVOC - Somatic Variant Oncogenicity Classifier

Welcome to SVOC!

SVOC (Somatic Variant Oncogenicity Classifier) is a SOP-driven tool for genome-wide somatic variant oncogenicity classification.

Two efficient modes were provided for accessing variant classification:

1. Data retrieval: Specific variants or genes can be rapidly queried through this mode. Results are retrieved directly from a database of over 450,000 pre-computed variants located in 758 cancer genes, typically within seconds. Querying by a gene name returns the classification records for all its documented variants stored in the database.

2. Online classification: For any one or more variants within the whole genome, a standardized VCF file can be uploaded via this mode. The system then executes a backend algorithm to parse and classify the submitted variants in real time.

Note: Currently, Data retrieval only supports the retrieval of SNVs based on the GRCh37/hg19 reference genome version. If you need to search for InDels or variants based on GRCh38/hg38, please use Online Classification and upload a VCF file containing the variant for real-time classification (VCF files with a single variant are also supported).

Data retrieval

Example

CHR-POS-REF-ALT 7-140453134-T-C, 7-140481402-C-T, 7-148508727-T-A, 13-28592642-C-A, 2-209113112-C-T, 12-25398284-C-G
Gene:Mutation CDS BRAF:c.1801A>G, EZH2:c.1937A>T, FLT3:c.2503G>T, IDH1:c.395G>A, KRAS:c.35G>C
Gene:Mutation AA BRAF:p.K601E, EZH2:p.Y646F, FLT3:p.D835Y, IDH1:p.R132H, KRAS:p.G12A
Gene TP53, PTEN, EGFR, PIK3CA, BRAF, ERBB2, BRCA1, BRCA2

Online classification

▪ Reference genome version:

▪ Upload file:

The processing time for the example file is approximately 8~10 minutes.

▪ Optional: provide your email to get notified when the job is completed.

Please note that by clicking "Submit", you confirm and warrant that you have the full right and authority to provide genomic variant data to SVOC, to analyze such data, and to obtain results on such data. You further confirm and warrant that the data does not contain any identifiable information. You also understand that the SVOC web server does not require user registration, so that your data is potentially accessible by third parties by decrypting URLs. Finally, you understand that any user data will be removed from the web server periodically, and it is your own responsibility to backup any data and results. You hereby irrevocably agree to hold the developers harmless from any form of liability, even if the data which you provide to SVOC becomes compromised.