SVOC - Somatic Variant Oncogenicity Classifier

Welcome to SVOC!

SVOC (Somatic Variant Oncogenicity Classifier) is a resource for genome-wide, guideline-driven oncogenicity classification of somatic variants. It currently encompasses classifications for approximately 200,000 somatic variants located in cancer hotspot genes or regions. For variants not yet in the database, an online algorithm is available to generate real-time classifications, ensuring genome-wide annotation capabilities.

SVOC web supports two ways for rapid retrieval: Single Variant or Gene Retrieval, and Batch Retrieval.

Note: Currently, Single Variant or Gene Retrieval only supports the retrieval of SNVs based on the GRCh37/hg19 reference genome version. If you need to search for InDels or variants based on GRCh38/hg38, please use Batch Retrieval and upload a VCF file containing the variant for real-time classification (VCF files with a single variant are also supported).

Single Variant or Gene Retrieval

Example

CHR-POS-REF-ALT 7-140453134-T-C, 7-140481402-C-T, 7-148508727-T-A, 13-28592642-C-A, 2-209113112-C-T, 12-25398284-C-G
Gene:Mutation CDS BRAF:c.1801A>G, EZH2:c.1937A>T, FLT3:c.2503G>T, IDH1:c.395G>A, KRAS:c.35G>C
Gene:Mutation AA BRAF:p.K601E, EZH2:p.Y646F, FLT3:p.D835Y, IDH1:p.R132H, KRAS:p.G12A
Gene TP53, PTEN, EGFR, PIK3CA, BRAF, ERBB2, BRCA1, BRCA2

Batch Retrieval

Classifying a large number of new variants (e.g., thousands in one request) by using the SVOC web server can be slow. If you need to classify thousands of variants, consider using the offline command-line scripts of SVOC and setting up an internal classification system for your site or institution.

Please provide a VCF file of your variants. For information on the VCF format see https://samtools.github.io/hts-specs/. It is sufficient to provide the first 8 columns of a VCF file without header. The maximum accepted file size is set at 2MB. Your upload will fail if you try to upload files larger than 2MB or if the extension of your file is not vcf. You will be able to retrieve your variants faster, if you upload them in smaller sets.

▪ Reference genome version:

▪ Upload file:

The processing time for the example file is approximately 8~10 minutes.

▪ Optional: provide your email to get notified when the job is completed.

Please note that by clicking "Submit", you confirm and warrant that you have the full right and authority to provide genomic variant data to SVOC, to analyze such data, and to obtain results on such data. You further confirm and warrant that the data does not contain any identifiable information. You also understand that the SVOC web server does not require user registration, so that your data is potentially accessible by third parties by decrypting URLs. Finally, you understand that any user data will be removed from the web server periodically, and it is your own responsibility to backup any data and results. You hereby irrevocably agree to hold the developers harmless from any form of liability, even if the data which you provide to SVOC becomes compromised.